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Positive feedback is denoted by (+) and negative feedback isdenoted by (?). The large arrows point to the fenestrations in the endothelium. The creation of a so-called bead pouch is a variation to fill cavities in the firstinterval of a two-stage exchange. fridgesor freezers, with proper labelling and coding of each sample allowing it to beretrieved easily, and matched (anonymously) to the correct study participant.Electronic barcode readers could be useful when there are many samples,because this reduces human coding errors

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